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Merck

Beclin-1 suppresses gastric cancer progression by promoting apoptosis and reducing cell migration.

Oncology letters (2017-11-23)
Yanfeng Wang, Jianying Xie, Hao Wang, Haixia Huang, Ping Xie
RESUMEN

To investigate Beclin-1 expression in gastric cancer and its clinical relevance, 60 samples were collected from patients with gastric carcinoma, which were subjected to immunohistochemical staining and analysis. Associations of Beclin-1 expression with the clinical parameters of the patients, including tumor size, histological differentiation and metastatic status, were examined by statistical analysis. The results demonstrated that Beclin-1 expression in gastric carcinoma tissue was significantly associated with the tumor, node, metastasis stage and tumor invasion status. Further experiments indicated that Beclin-1 overexpression promoted MKN-45 gastric cancer cell apoptosis and inhibited their migration. These data suggested that Beclin-1 was a suppressor of tumorigenesis in gastric cancer and a potential therapeutic target for patients with gastric cancer.

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Anti-β-actina monoclonal antibody produced in mouse, clone AC-15, ascites fluid