T8276

Anti-TRPC1 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• Sinónimos: Transient receptor potential cation channel, subfamily C, member 1
• MDL number: MFCD02686004
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: lyophilized powder
• species reactivity: rat
• technique(s): immunohistochemistry: suitable; western blot (chemiluminescent): suitable
• UniProt accession no.: Q9QX01
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... TRPC1(7220) ; mouse ... Trpc1(22063) ; rat ... Trpc1(89821)

Descripción

General description

Transient receptor potential cation channel subfamily C member 1 (TRPC1) is encoded by the gene mapped to human chromosome 3q22-24. The encoded protein is a member of the transient receptor potential (TRP) superfamily of cation channels and is distributed in both glomeruli and glomerular mesangial cells.

Immunogen

Synthetic protein corresponding to amino acids 557-571 of human TRPC1 (GenBank^® Accession No. P48995). The epitope is identical in mouse and rat and highly homologous in bovine and Xenopus.

Biochem/physiol Actions

Transient receptor potential cation channel subfamily C member 1 (TRPC1) facilitates Ca²⁺ entry upon store depletion in a variety of cell types by forming a multimeric complex with other TRPCs. The encoded protein is implicated in the odontoblast-like differentiation of human dental pulp cells (hDPCs). Mutation in the gene is associated with the development type 2 diabetes mellitus (T2D). Decreased expression of the gene leads to hepatocellular carcinoma cell proliferation and thus, TRPC1 can be considered as a potential therapeutic target for hepatocellular carcinoma.

Physical form

Lyophilized at 0.3 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

Legal Information

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Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• pictograms: GHS06,GHS09
• signalword: Danger
• hcodes: H301 + H311,H411
• pcodes: P273 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P391 - P501
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Chronic 2
• supp_hazards: EUH032
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges