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S166

Saclofen

solid

Sinónimos:

β-(Aminomethyl)-4-chlorobenzeneethanesulfonic acid

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Tamaño de envaseSKUDisponibilidadPrecio
5 mg
Comprobar disponibilidad del carrito
US$ 416,00

Acerca de este artículo

Fórmula empírica (notación de Hill):
C9H12ClNO3S
Número CAS:
125464-42-8
Peso molecular:
249.71
NACRES:
NA.32
PubChem Substance ID:
329824485
UNSPSC Code:
51111800
MDL number:
MFCD00216817
Form:
solid
Quality level:
200

US$ 416,00

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form

solid

Quality Level

200

color

white

solubility

0.1 M NaOH: 20 mg/mL

SMILES string

NCC(CS(O)(=O)=O)c1ccc(Cl)cc1

InChI

1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14)

InChI key

JYLNVJYYQQXNEK-UHFFFAOYSA-N

Gene Information

human ... GABBR1(2550), GABBR2(9568)
mouse ... GABBR1(54393), GABBR2(242425)
rat ... GABBR1(81657), GABBR2(83633)

Application

Saclofen has been used to prevent the inhibitory action of oxytocin on capsaicin-induced glutamatergic spontaneous excitatory transmission in rat neurons.[1]
Saclofen has been used as a GABAB receptor antagonist to study the analgesic effect of repeated injections of oxycodone in rats.

Biochem/physiol Actions

Saclofen might possess sympathetic nervous system-dependent anti-inflammatory action.[2]
Saclofen is the sulphonic analog of baclofen and is a selective GABAB receptor antagonist.

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Este artículo
A6566M196B5399
Saclofen solid

Sigma-Aldrich

S166

Saclofen

2-Hydroxysaclofen ≥98% (TLC), solid

Sigma-Aldrich

A6566

2-Hydroxysaclofen

(+)-α-Methyl-4-carboxyphenylglycine solid

Sigma-Aldrich

M196

(+)-α-Methyl-4-carboxyphenylglycine

(±)-Baclofen ≥98% (HPLC), solid

Sigma-Aldrich

B5399

(±)-Baclofen

form

solid

form

solid

form

solid

form

solid

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

solubility

0.1 M NaOH: 20 mg/mL

solubility

H2O: 1 mg/mL, 0.1 M HCl: 1.2 mg/mL, methanol: 1.4 mg/mL, DMSO: 28 mg/mL, 0.1 M NaOH: 9.5 mg/mL

solubility

0.1 M NaOH: 15 mg/mL

solubility

1 M HCl: 50 mg/mL

color

white

color

white

color

-

color

white to very faintly yellow

Gene Information

human ... GABBR1(2550), GABBR2(9568)
mouse ... GABBR1(54393), GABBR2(242425)
rat ... GABBR1(81657), GABBR2(83633)

Gene Information

human ... GABBR1(2550), GABBR2(9568)

Gene Information

rat ... Grm1(24414)

Gene Information

human ... GABBR1(2550), GABBR2(9568)
rat ... Gabbr1(81657), Gabra2(29706)

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000544335
0000544335
0000510273
0000510273
0000500585

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Minoru Miyazato et al.
The Journal of urology, 179(3), 1178-1183 (2008-01-22)
We investigated the effects of intrathecal application of gamma-aminobutyric acid A and B receptor agonists on detrusor overactivity in spinal cord injured rats. Adult female Sprague-Dawley rats were used. At 4 weeks after Th9-10 spinal cord transection awake cystometry and
Faraz Mahdian Dehkordi et al.
The Korean journal of pain, 32(3), 160-167 (2019-07-02)
Pain is a complex mechanism which involves different systems, including the opioidergic and GABAergic systems. Due to the side effects of chemical analgesic agents, attention toward natural agents have been increased. Artemisinin is an herbal compound with widespread modern and
Gabriel S Bassi et al.
Naunyn-Schmiedeberg's archives of pharmacology, 389(8), 851-861 (2016-04-24)
Recent studies have demonstrated that the central nervous system controls inflammatory responses by activating complex efferent neuroimmune pathways. The present study was designed to evaluate the role that central gamma-aminobutyric acid type B (GABA-B) receptor plays in neutrophil migration in
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Número de artículo de comercio global

SKUGTIN
SAB5701894-100UL04065267678719
SAB5700317-100UL04065265172622
SAB5701958-100UL04065267679358
S166-5MG04061836912925

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