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S0693

Sigma-Aldrich

SB 204741

>98% (HPLC)

Sinónimos:

N-(1-Methyl-1H-5-indolyl)-N′-(3-methyl-5-isothiazolyl)urea

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About This Item

Fórmula empírica (notación de Hill):
C14H14N4OS
Número de CAS:
152239-46-8
Peso molecular:
286.35
MDL number:
MFCD00923644
UNSPSC Code:
12352200
PubChem Substance ID:
24278321
NACRES:
NA.77

Quality Level

100

assay

>98% (HPLC)

form

solid

color

off-white to tan

solubility

DMSO: soluble >20 mg/mL

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1

InChI

1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)

InChI key

USFUFHFQWXDVMH-UHFFFAOYSA-N

Gene Information

human ... DRD2(1813) , DRD3(1814) , DRD5(1816) , HTR1E(3354) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358)
rat ... Adra1a(29412) , Gabra2(29706) , Htr1a(24473) , Htr2b(29581) , Htr3a(79246)

Application

SB 204741 has been used as a 5-hydroxytryptamine receptor 2B (Htr2B) antagonist:
  • to inhibit Htr2b signaling to test its effect on hepatic stellate cell (HSC) activation in three-month-old adult zebrafish
  • to test its effect on the inhibition of fluoxetine effects in depressive-like behavioral studies in mice
  • to test its effect in reducing scratching behavior evoked by sertraline in mice

Biochem/physiol Actions

SB 204741 reduces the synaptic facilitation induced by the low dose of buprenorphine in spinal C-fiber synapses.
5-HT2B serotonin receptor antagonist.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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