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GW21017

Sigma-Aldrich

Anti-Tenascin antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-Cytotactin, Anti-Neuronectin, Anti-Tenascin C (hexabrachion)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-21017

technique(s)

western blot: suitable

NCBI accession no.

NP_002151.1

UniProt accession no.

P24821

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TNC(3371)

Immunogen

Immunogen Sequence: GI # 4504549, sequence 18-175
Recombinant tenascin C (hexabrachion)

Application

Anti-Tenascin antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200. It is also used for immunohistology.

Biochem/physiol Actions

Tenascin-C (TNC) is an extracellular matrix protein that is expressed at low levels in normal adult tissue but is highly expressed around many tumors including ovarian tumors. High levels are observed in many diseases like heart failure, thrombosis, atherosclerosis and cancer. It plays an indispensable role in tumor development. Expression of this gene is induced by growth factors as well as mechanical strain in fibroblast. It is up-regulated within glioma tissues and cultured glioma cell lines. TNC possesses a multi-modular structure with a variety of functional properties.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

D Tastekin et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(7), 6619-6625 (2014-04-04)
Tenascin-C (TNC) is a key molecule in tissue remodeling, and high levels are observed in many diseases, including heart failure, thrombosis, atherosclerosis, and cancer. High TNC expression by immunohistochemical analysis has been shown in invasive and metastasizing tissues from a
Tastekin Didem et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(7), 6777-6782 (2014-04-12)
Tenascin-C (TNC) is an extracellular matrix protein that is expressed at low levels in normal adult tissue but is highly expressed around many tumors including ovarian tumors. The objective of this study was to determine the clinical significance of the
Yucal Wang et al.
Oncology research, 20(11), 509-516 (2013-09-26)
Osteosarcoma (OS) is a kind of malignancy wherein the tumor cells form malignant bone-like or bone tissue. Tenascin-C (TN-C), an important extracellular matrix (ECM) protein, plays an indispensable role in tumor development. However, its regulatory factors, expression, and function in
Nicole Brösicke et al.
Cell and tissue research, 354(2), 409-430 (2013-08-22)
The extracellular matrix (ECM) protein tenascin-C (TN-C) is upregulated within glioma tissues and cultured glioma cell lines. TN-C possesses a multi-modular structure and a variety of functional properties have been reported for its domains. We describe five novel monoclonal antibodies
Daniel J Gibson et al.
Investigative ophthalmology & visual science, 54(7), 4776-4781 (2013-06-27)
To determine the topographical location and time course of development of corneal haze in a phototherapeutic keratectomy model using slit lamp examination, macrophotography, quantitative image analysis, and immunofluorescence staining of corneal sections. Rabbit corneas were ablated with an excimer laser

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