C130
Chloro-APB hydrobromide
solid
Sinónimos:
(±)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide, (±)-SKF-82958 hydrobromide, 6-Chloro-N-allyl-SKF-38393 hydrobromide
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C19H20ClNO2 · HBr
Número CAS:
Peso molecular:
410.73
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
solid
Quality level:
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Servicio técnico
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solid
Quality Level
color
tan
solubility
H2O: 3.7 mg/mL, aqueous base: unstable, ethanol: soluble
storage temp.
2-8°C
SMILES string
Br.Oc1cc2C(CN(CCc2c(Cl)c1O)CC=C)c3ccccc3
InChI
1S/C19H20ClNO2.BrH/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13;/h2-7,11,16,22-23H,1,8-10,12H2;1H
InChI key
WLXGFAVTAAQOFH-UHFFFAOYSA-N
Gene Information
human ... DRD1(1812)
Application
Chloro-APB hydrobromide has been used to pharmacologically stimulate D1 dopamine receptors and study its influence on locomotor response in fat mass and obesity-associated protein (FTO) deficient dopamine D1 receptor-expressing medium spiny neurons (D1 MSNs) of mice.[1]
Biochem/physiol Actions
Disclaimer
Light sensitive
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Thomas F Tropea et al.
Biological psychiatry, 63(11), 1066-1074 (2008-02-16)
Prenatal exposure to cocaine can impede normal brain development, triggering a range of neuroanatomical and behavioral anomalies that are evident throughout life. Mouse models have been especially helpful in delineating neuro-teratogenic consequences after prenatal exposure to cocaine. The present study
K D Carr et al.
Neuroscience, 165(4), 1074-1086 (2009-11-26)
Previous findings suggest that neuroadaptations downstream of D-1 dopamine (DA) receptor stimulation in nucleus accumbens (NAc) are involved in the enhancement of drug reward by chronic food restriction (FR). Given the high co-expression of D-1 and GluR1 AMPA receptors in
Thomas P Giordano et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(50), 17051-17062 (2010-12-17)
L-type Ca(2+) channel (LTCC)-activated signaling cascades contribute significantly to psychostimulant-induced locomotor sensitization; however, the precise contribution of the two brain-specific subunits Ca(v)1.2 and Ca(v)1.3 remains mostly unknown. In this study, by using amphetamine and cocaine locomotor sensitization in mutant mice
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| C130-5MG | 04061832081397 |
| C130-25MG | 04061833467329 |
| C130-100MG | 04061833467312 |