B3811

B-9430 trifluoroacetate salt

≥98% (HPLC)

• Sinónimos: D-Arg-Arg-Pro-Hyp-Gly-Igl-Ser-D-Igl-Oic-Arg trifluoroacetate salt, D-Arg-[Hyp³, Igl⁵, D-Igl⁷, Oic⁸]-Bradykinin trifluoroacetate salt
• Fórmula empírica (notación de Hill): C₆₄H₉₅N₁₉O₁₃ · xC₂HF₃O₂
• Número de CAS: 180981-09-3
• Peso molecular: 1338.56 (free base basis)
• UNSPSC Code: 12352200

Propiedades

• assay: ≥98% (HPLC)
• form: solid
• storage condition: protect from light; under inert gas
• solubility: H₂O: ≥2 mg/mL
• shipped in: wet ice
• storage temp.: −20°C

Descripción

Amino Acid Sequence

Arg-Arg-Pro-Hyp-Gly-Igl-Ser-Igl-Oic-Arg

Biochem/physiol Actions

B-9430 was developed by Gera at the Stewart laboratory¹ and is a stable, potent, and long lasting Bradykinin (BK) antagonist, a candidate anti-inflammatory drug. B-9430 shows potency at bradykinin B2 (pA₂ = 8.6) and B1 receptors (pA₂ = 7.3). Bradykinin is an important growth factor for small-cell lung cancer (SCLC) and prostate cancer (PC). BK receptors are expressed on almost all lung cancer cell lines and on many PC cells. B-9430 is very resistant to kinases and thus shows a very long action in vivo. This peptide is unique among bradykinin antagonists in that it is active after oral administration.

Caution

Product is air and light sensitive. Store in the dark.

Información de seguridad

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable