B2432
8-Bromoadenosine-3′,5′-cyclic monophosphorothioate, Rp-isomer
≥98% (HPLC), solid
Sinónimos:
Rp-8-Br-cAMPS
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About This Item
Fórmula empírica (notación de Hill):
C10H10BrN5O5PSNa
Peso molecular:
446.15
UNSPSC Code:
41106305
NACRES:
NA.77
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Quality Level
assay
≥98% (HPLC)
form
solid
packaging
vial of 5 μmol
solubility
water: soluble
storage temp.
−20°C
Biochem/physiol Actions
Competitive inhibitor of cyclic AMP-dependent protein kinase A (PKA) type I and II. Membrane-permeable analog of the cAMP inhibitor Rp-cAMPS (Prod. No. A-165).
Features and Benefits
This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
B T Gjertsen et al.
The Journal of biological chemistry, 270(35), 20599-20607 (1995-09-01)
Novel (Rp)-cAMPS analogs differed widely in ability to antagonize cAMP activation of pure cAMP-dependent protein kinase I and II and to antagonize actions of cAMP on gene expression, shape change, apoptosis, DNA replication, and protein phosphorylation in intact cells. These
Angeline Eymery et al.
Development (Cambridge, England), 143(15), 2767-2779 (2016-06-19)
Oocytes develop the competence for meiosis and early embryogenesis during their growth. Setdb1 is a histone H3 lysine 9 (H3K9) methyltransferase required for post-implantation development and has been implicated in the transcriptional silencing of genes and endogenous retroviral elements (ERVs).
Ho Lin et al.
Endocrinology, 150(1), 396-403 (2008-08-30)
The roles of cyclin-dependent kinase 5 (Cdk5) in central nervous system and neurodegenerative diseases have been intensely investigated in recent decades. Because protein expressions of Cdk5 and its regulator, p35, have been identified in Leydig cells, it is informative to
Mei-Chih Chen et al.
American journal of physiology. Cell physiology, 299(2), C516-C527 (2010-05-14)
The signaling mechanisms underlying cell differentiation have been extensively studied with the use of rat PC12 cells as a model system. Nerve growth factor (NGF) is a trophic factor inducing PC12 cell differentiation through the activation of the p35/cyclin-dependent kinase
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