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Certificado de origen (COO)/COA

346R-1

Villin (EP163) Rabbit Monoclonal Primary Antibody

Name: Villin (EP163) Rabbit Monoclonal Primary Antibody
Brand: SIGMA

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About This Item

Código UNSPSC:

12352203

NACRES:

NA.41

En este momento no podemos mostrarle ni los precios ni la disponibilidad

origen biológico

rabbit

Nivel de calidad

100
500

conjugado

unconjugated

forma del anticuerpo

culture supernatant

tipo de anticuerpo

primary antibodies

clon

EP163, monoclonal

descripción

(For In Vitro Diagnostic Use in Select Regions (See Chart))

Formulario

buffered aqueous solution

reactividad de especies

human

envase

bottle of 1.0 mL predilute (346R-17)
bottle of 7.0 mL predilute (346R-18)
vial of 0.1 mL concentrate (346R-14)
vial of 0.5 mL concentrate (346R-15)
vial of 1.0 mL concentrate (346R-16)

fabricante / nombre comercial

Cell Marque^®

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotipo

IgG

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

Información sobre el gen

human ... VIL1(7429)

Descripción general

Villin is a 95 kD glycoprotein of microvilli associated with rootlet formation in gastrointestinal mucosal epithelium. Anti-villin labels the brush border area in the gastrointestinal mucosal epithelium.¹ This antibody has been useful in differentiating gastrointestinal adenocarcinoma, neuroendocrine carcinomas, and ovarian adenocarcinomas from adenocarcinomas of other organs.^2-5 This antibody also labels Merkel cells of the skin.⁶

Calidad

IVD

RUO

Ligadura / enlace

Villin Positive Control Slides, Product No. 346S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparación

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Otras notas

For Technical Service please contact: 800-665-7284 or email: [email protected]

Información legal

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

0000315439

0000184781

0000115778

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Identification of Merkel cells by an antibody to villin.

K Toyoshima et al.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 46(11), 1329-1334 (1998-10-17)

Merkel cells represent a population of epithelial cells in the skin and oral mucosa. Although Merkel cells are reliably distinguishable from other epithelial cells at the ultrastructural level, these cells are usually not discernible by standard light microscopy and need

Immunoexpression of villin in neuroendocrine tumors and its diagnostic implications.

P J Zhang et al.

Archives of pathology & laboratory medicine, 123(9), 812-816 (1999-08-24)

Villin, a 95-kd cytoskeletal protein associated with axial microfilament bundles of brush border microvilli, is mostly restricted to intestinal glandular tumors. Villin immunoexpression was recently observed in a small number of carcinoids of the intestinal tract and lung, but its

Mucinous and nonmucinous bronchioloalveolar adenocarcinomas have distinct staining patterns with thyroid transcription factor and cytokeratin 20 antibodies.

N S Goldstein et al.

American journal of clinical pathology, 116(3), 319-325 (2001-09-14)

We studied 14 mucinous and 26 nonmucinous bronchioloalveolar adenocarcinomas (BACs) with thyroid transcription factor (TTF), cytokeratin (CK) 7, CK20, and villin to characterize their staining patterns with these antibodies and identify staining differences between the neoplasms. We also stained 11

Villin, cytokeratin 7, and cytokeratin 20 expression in pulmonary adenocarcinoma with ultrastructural evidence of microvilli with rootlets.

J Tan et al.

Human pathology, 29(4), 390-396 (1998-05-01)

Villin (V) is a glycoprotein of microvilli associated with rootlet formation. Most colonic adenocarcinomas have a V positive (+), cytokeratin (CK) 20 (+), CK7-negative (-) immunophenotype; most lung adenocarcinomas have a CK20(-), CK7(+) immunophenotype. The reports of villin immunoreactivity in

Colonic adenocarcinoma metastatic to the urinary tract versus primary tumors of the urinary tract with glandular differentiation: a report of 7 cases and investigation using a limited immunohistochemical panel.

Pheroze Tamboli et al.

Archives of pathology & laboratory medicine, 126(9), 1057-1063 (2002-09-03)

To determine whether a limited immunohistochemical panel can help differentiate metastatic colonic adenocarcinoma from primary enteric-type adenocarcinoma of the urinary tract and urothelial (transitional cell) carcinoma with glandular differentiation, which appear morphologically similar but most often necessitate different treatment protocols.

Artículos

Immunohistochemistry Applications in Gastrointestinal Cancer

Colorectal cancer is the third most common cancer in both men and women. An estimated 136,000 cases of colorectal cancer are expected to occur in 2016.

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