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Key Documents

ABT110

Sigma-Aldrich

Anti-SDHD (CybS) Antibody

from rabbit, purified by affinity chromatography

Sinónimos:

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial, CybS, CII-4, QPs3, Succinate dehydrogenase complex subunit D, Succinate-ubiquinone oxidoreductase cytochrome b small subunit, Succinate-ubiquinone reductase membrane anchor s

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, mouse

species reactivity (predicted by homology)

sheep (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), bovine (based on 100% sequence homology)

technique(s)

immunocytochemistry: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... SDHD(6392)

General description

Succinate dehydrogenase complex subunit D (SDHD) is a member of the CybS family and is one of four subunits of the succinate dehydrogenase (SDH) complex involved in the electron transport chain of the mitochondria. The specific role of SDH is to transfer electrons from succinate to ubiquinone, and the SDHD subunit is involved in anchoring the SDH complex to the inner mitochondrial membrane. Defective SDHD has been linked to Carney-Stratakis syndrome, a condition characterized by concurrent paraganglioma and gastric stromal sarcomas.

Specificity

Other homologies: Rat (92% sequence homology).
This antibody recognizes the Topological domain (mitochondrial matrix) of SDHD (CybS).

Immunogen

Epitope: Topological domain (mitochondrial matrix)
KLH-conjugated linear peptide corresponding to the Topological domain of human SDHD (CybS).

Application

Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected SDHD (CybS) in NIH/3T3 and HeLa cells.
Research Category
Cell Structure
Research Sub Category
Cytoskeleton
This Anti-SDHD (CybS) Antibody is validated for use in Western Blotting, ICC for the detection of SDHD (CybS).

Quality

Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected SDHD (CybS) in 10 µg of HeLa cell lysate.

Target description

~11 kDa observed. An uncharacterized band may be observed at ~25 kDa in some cell lysates.

Physical form

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
HeLa cell lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Charlotte L Alston et al.
Human genetics, 134(8), 869-879 (2015-05-27)
Succinate dehydrogenase (SDH) is a crucial metabolic enzyme complex that is involved in ATP production, playing roles in both the tricarboxylic cycle and the mitochondrial respiratory chain (complex II). Isolated complex II deficiency is one of the rarest oxidative phosphorylation
Yoshihiro Hayashi et al.
Cancer discovery, 8(11), 1438-1457 (2018-08-25)
Myelodysplastic syndromes (MDS) are heterogeneous hematopoietic disorders that are incurable with conventional therapy. Their incidence is increasing with global population aging. Although many genetic, epigenetic, splicing, and metabolic aberrations have been identified in patients with MDS, their clinical features are

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