07-218
Anti-Notch1 Antibody, extracellular domain
Upstate®, from rabbit
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
origen biológico
rabbit
Nivel de calidad
tipo de anticuerpo
primary antibodies
clon
polyclonal
reactividad de especies
rat, mouse
fabricante / nombre comercial
Upstate®
técnicas
western blot: suitable
isotipo
IgG
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
Información sobre el gen
human ... NOTCH1(4851)
Descripción general
The Notch protein family is a group of highly conserved proteins important in the determination of cell fate and maintenance of progenitors in many developmental systems. This family of proteins function both as membrane cell receptors and as transcription factors. Activation of Notch by cell-cell interactions causes a transcription inhibitory effect that enables inhibition of differentiation in some cells but not in others. As a consequence, some cells adopt a particular fate while other progenitors remain uncommitted. The Notch protein is important in cell fate during myogenesis, neurogenesis, oogenesis, and wing and eye development in Drosophila. In mammals, four Notch genes were identified (Notch 1-4) that are expressed in a wide variety of cells and play a crucial role in differentiation and development.
Especificidad
Notch1
Inmunógeno
N-terminal GST fusion protein corresponding to residues 381-853 of rat Notch1
Aplicación
Anti-Notch1 Antibody, extracellular domain is a high quality Rabbit Polyclonal Antibody for the detection of Notch1 & has been validated in WB.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
Used in mouse in the following publication: Gulino, R., et al, European Journal of Neuroscience, Vol. 31, pp. 1423–1434, 2010.
Calidad
Routinely evaluated by immunoblot on RIPA lysates from L/N17 rat Notch1 transfected fibroblast cells
Descripción de destino
260kDa
Ligadura / enlace
Replaces: 04-1046
Forma física
Format: Purified
Protein A chromatography
Protein A purified immunoglobulin presented in 0.1M Tris-Glycine, 0.15M NaCl, and 0.05% Sodium Azide, pH 7.4
Almacenamiento y estabilidad
Stable for 1 year at 2-8°C from date of receipt.
Nota de análisis
Control
L/N17 transfected Notch1 cell lysate
L/N17 transfected Notch1 cell lysate
Información legal
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10-13 - German Storage Class 10 to 13
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Notch-1 controls the expression of fatty acid-activated transcription factors and is required for adipogenesis
Garces, C, et al
The Journal of Biological Chemistry, 272, 29729-29734 (1997)
C M Blaumueller et al.
Cell, 90(2), 281-291 (1997-07-25)
Previous models for signal transduction via the Notch pathway have depicted the full-length Notch receptor expressed at the cell surface. We present evidence demonstrating that the Notch receptor on the plasma membrane is cleaved. This cleavage is an evolutionarily conserved
NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa
Oswald, F, et al
Molecular and cellular biology, 18, 2077-2088 (1998)
Notch signaling: direct or what?
Weinmaster, G
Current Opinion in Genetics & Development, 8, 436-442 (1998)
G Struhl et al.
Cell, 93(4), 649-660 (1998-05-30)
The Drosophila Notch (N) gene encodes a conserved single-pass transmembrane receptor that transduces extracellular signals controlling cell fate. Here, we present evidence that the intracellular domain of Notch gains access to the nucleus in response to ligand, possibly through a
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