UPF2
UPF2 regulator of nonsense transcripts homolog (yeast)
Sinónimos:
HUPF2, RENT2, smg-3
Especie:
Human UPF2 (26019), Mouse Upf2 (326622), Rat Upf2 (361271), cow UPF2 (781181), fruit fly Upf2 (31724), Zebrafish upf2 (569006), chicken UPF2 (419100), sheep UPF2 (101116751), Domestic Rabbit UPF2 (100354055), domestic guinea pig Upf2 (100734921) ...Más
ID UniProtKB:
ID del gen:
- Human(26019) Summary: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008]
- Mouse(326622) UPF2 regulator of nonsense transcripts homolog (yeast)
- Rat(361271) UPF2 regulator of nonsense transcripts homolog (yeast)
- cow(781181) UPF2 regulator of nonsense transcripts homolog (yeast)
- fruit fly(31724) CG2253 gene product from transcript CG2253-RA
- Zebrafish(569006) UPF2 regulator of nonsense transcripts homolog (yeast)
- chicken(419100) UPF2 regulator of nonsense transcripts homolog (yeast)
- sheep(101116751) UPF2 regulator of nonsense transcripts homolog (yeast)
- Domestic Rabbit(100354055) UPF2 regulator of nonsense transcripts homolog (yeast)
- domestic guinea pig(100734921) UPF2 regulator of nonsense transcripts homolog (yeast)
- naked mole-rat(101707612) UPF2 regulator of nonsense transcripts homolog (yeast)
- dog(487130) UPF2 regulator of nonsense transcripts homolog (yeast)
- domestic cat(101085899) UPF2 regulator of nonsense transcripts homolog (yeast)
- Horse(100069342) UPF2 regulator of nonsense transcripts homolog (yeast)
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