TOP2A

topoisomerase (DNA) II alpha 170kDa

Sinónimos:

TOP2, TP2A

Especie:

Human TOP2A (7153), Mouse Top2a (21973), Rat Top2a (360243), dog TOP2A (480525), Domestic Rabbit TOP2A (100357676), Zebrafish top2a (323733), chicken TOP2A (395570), sheep TOP2A (101108762), domestic guinea pig Top2a (100730168), cow TOP2A (787696)

ID UniProtKB:

P11388, B2RTS1, Q71UN1, Q71UQ5, Q9HB24, Q9HB25, Q9HB26, Q9UP44

ID del gen:

Human(7153) Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
Mouse(21973) topoisomerase (DNA) II alpha
Rat(360243) topoisomerase (DNA) II alpha
dog(480525) topoisomerase (DNA) II alpha 170kDa
Domestic Rabbit(100357676) topoisomerase (DNA) II alpha 170kDa
Zebrafish(323733) topoisomerase (DNA) II alpha
chicken(395570) topoisomerase (DNA) II alpha 170kDa
sheep(101108762) topoisomerase (DNA) II alpha 170kDa
domestic guinea pig(100730168) topoisomerase (DNA) II alpha 170kDa
cow(787696) topoisomerase (DNA) II alpha 170kDa
domestic cat(101083813) topoisomerase (DNA) II alpha 170kDa

Productos (38)
Artículos con revisión científica externa. (234)

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