TNFSF12
tumor necrosis factor (ligand) superfamily, member 12
Sinónimos:
APO3L, DR3LG, TWEAK
Especie:
Human TNFSF12 (8742), Mouse Tnfsf12 (21944), Rat Tnfsf12 (360548), domestic guinea pig Tnfsf12 (100713543), domestic cat TNFSF12 (101098755), Zebrafish tnfsf12 (567542), dog TNFSF12 (100568280), cow TNFSF12 (100568284), cow TNFSF12 (100551513), Domestic Rabbit TNFSF12 (100356651) ...Más
ID UniProtKB:
ID del gen:
- Human(8742) Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
- Mouse(21944) tumor necrosis factor (ligand) superfamily, member 12
- Rat(360548) tumor necrosis factor ligand superfamily member 12
- domestic guinea pig(100713543) tumor necrosis factor (ligand) superfamily, member 12
- domestic cat(101098755) tumor necrosis factor (ligand) superfamily, member 12
- Zebrafish(567542) tumor necrosis factor (ligand) superfamily, member 12
- dog(100568280) tumor necrosis factor (ligand) superfamily, member 12
- cow(100568284) tumor necrosis factor (ligand) superfamily, member 12
- cow(100551513) tumor necrosis factor (ligand) superfamily, member 12
- Domestic Rabbit(100356651) tumor necrosis factor (ligand) superfamily, member 12
- Horse(100061872) tumor necrosis factor (ligand) superfamily, member 12
- sheep(101122801) tumor necrosis factor (ligand) superfamily, member 12
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Proteins
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Descripción
Especie
TWEAK, humano, Human TWEAK is a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis.,
Especie
human