SPG21
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
Sinónimos:
ACP33, GL010, MAST
Especie:
Human SPG21 (51324), Mouse Spg21 (27965), Rat Spg21 (300791), domestic cat SPG21 (101096987), dog SPG21 (487599), Zebrafish spg21 (406704), domestic guinea pig Spg21 (100713790), cow SPG21 (404069), sheep SPG21 (101117420), naked mole-rat Spg21 (101696663)
ID UniProtKB:
ID del gen:
- Human(51324) Summary: The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. At least three different transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(27965) spastic paraplegia 21 homolog (human)
- Rat(300791) spastic paraplegia 21 homolog (human)
- domestic cat(101096987) spastic paraplegia 21 (autosomal recessive, Mast syndrome)
- dog(487599) spastic paraplegia 21 (autosomal recessive, Mast syndrome)
- Zebrafish(406704) spastic paraplegia 21 (H. sapiens)
- domestic guinea pig(100713790) spastic paraplegia 21 (autosomal recessive, Mast syndrome)
- cow(404069) spastic paraplegia 21 (autosomal recessive, Mast syndrome)
- sheep(101117420) spastic paraplegia 21 (autosomal recessive, Mast syndrome)
- naked mole-rat(101696663) spastic paraplegia 21 (autosomal recessive, Mast syndrome)
- chicken(415526) spastic paraplegia 21 (autosomal recessive, Mast syndrome)
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