SESN1
sestrin 1
Sinónimos:
PA26, SEST1
Especie:
Human SESN1 (27244), Mouse Sesn1 (140742), Rat Sesn1 (294518), domestic cat SESN1 (101099380), cow SESN1 (538226), sheep SESN1 (101115970), dog SESN1 (481956), Zebrafish sesn1 (436933), naked mole-rat Sesn1 (101699483), chicken SESN1 (421766)
ID UniProtKB:
ID del gen:
- Human(27244) Summary: This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
- Mouse(140742) sestrin 1
- Rat(294518) sestrin 1
- domestic cat(101099380) sestrin 1
- cow(538226) sestrin 1
- sheep(101115970) sestrin 1
- dog(481956) sestrin 1
- Zebrafish(436933) sestrin 1
- naked mole-rat(101699483) sestrin 1
- chicken(421766) sestrin 1
- domestic guinea pig(100713452) sestrin 1
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-sestrin 1 antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
western blot
western blot