RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
Sinónimos:
AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2
Especie:
Human RUNX1T1 (862), Mouse Runx1t1 (12395), Rat Runx1t1 (362489), domestic guinea pig Runx1t1 (100724443), naked mole-rat Runx1t1 (101707177), cow RUNX1T1 (538628), sheep RUNX1T1 (101113340), dog RUNX1T1 (487044), domestic cat RUNX1T1 (101080942), Horse RUNX1T1 (100050630) ...Más
ID UniProtKB:
ID del gen:
- Human(862) Summary: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
- Mouse(12395) runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
- Rat(362489) runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
- domestic guinea pig(100724443) runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
- naked mole-rat(101707177) runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
- cow(538628) runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
- sheep(101113340) runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
- dog(487044) runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
- domestic cat(101080942) runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
- Horse(100050630) runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
- Zebrafish(767809) runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
- chicken(395503) runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
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