RNF34
ring finger protein 34, E3 ubiquitin protein ligase
Sinónimos:
CARP-1, CARP1, RFI, RIF, RIFF, hRFI
Especie:
Human RNF34 (80196), Mouse Rnf34 (80751), Rat Rnf34 (282845), sheep RNF34 (101102266), domestic guinea pig Rnf34 (100715758), naked mole-rat Rnf34 (101725498), cow RNF34 (506764), chicken RNF34 (416843), dog RNF34 (477470), domestic cat RNF34 (101094706)
ID UniProtKB:
ID del gen:
- Human(80196) Summary: The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]
- Mouse(80751) ring finger protein 34
- Rat(282845) ring finger protein 34, E3 ubiquitin protein ligase
- sheep(101102266) ring finger protein 34, E3 ubiquitin protein ligase
- domestic guinea pig(100715758) ring finger protein 34, E3 ubiquitin protein ligase
- naked mole-rat(101725498) ring finger protein 34, E3 ubiquitin protein ligase
- cow(506764) ring finger protein 34
- chicken(416843) ring finger protein 34, E3 ubiquitin protein ligase
- dog(477470) ring finger protein 34, E3 ubiquitin protein ligase
- domestic cat(101094706) ring finger protein 34, E3 ubiquitin protein ligase
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