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Merck

PSMB11

proteasome (prosome, macropain) subunit, beta type, 11

Sinónimos:
BETA5T
Especie:
Human PSMB11 (122706), Mouse Psmb11 (73902), Rat Psmb11 (290206), naked mole-rat Psmb11 (101708621), domestic guinea pig Psmb11 (100718045), sheep PSMB11 (101122952), Zebrafish psmb11 (64279), cow PSMB11 (538873), dog PSMB11 (490604), domestic cat PSMB11 (101095263)
ID UniProtKB:
A5LHX3
ID del gen:
  • Human(122706) Summary: Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 [PubMed 17540904]
  • Mouse(73902) proteasome (prosome, macropain) subunit, beta type, 11
  • Rat(290206) proteasome (prosome, macropain) subunit, beta type, 11
  • naked mole-rat(101708621) proteasome (prosome, macropain) subunit, beta type, 11
  • domestic guinea pig(100718045) proteasome (prosome, macropain) subunit, beta type, 11
  • sheep(101122952) proteasome (prosome, macropain) subunit, beta type, 11
  • Zebrafish(64279) proteasome (prosome, macropain) subunit, beta type, 11
  • cow(538873) proteasome (prosome, macropain) subunit, beta type, 11
  • dog(490604) proteasome (prosome, macropain) subunit, beta type, 11
  • domestic cat(101095263) proteasome (prosome, macropain) subunit, beta type, 11

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