PML
promyelocytic leukemia
Sinónimos:
MYL, PP8675, RNF71, TRIM19
Especie:
Human PML (5371), Mouse Pml (18854), Rat Pml (315713), chicken PML (415302), chicken PML (415304), domestic cat PML (101086975), dog PML (487641), sheep PML (101111580), cow PML (100138545), Horse PML (100062744) ...Más
ID UniProtKB:
ID del gen:
- Human(5371) Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
- Mouse(18854) promyelocytic leukemia
- Rat(315713) promyelocytic leukemia
- chicken(415302) promyelocytic leukemia
- chicken(415304) promyelocytic leukemia
- domestic cat(101086975) promyelocytic leukemia
- dog(487641) promyelocytic leukemia
- sheep(101111580) promyelocytic leukemia
- cow(100138545) promyelocytic leukemia
- Horse(100062744) promyelocytic leukemia
- naked mole-rat(101707749) promyelocytic leukemia
- domestic guinea pig(100720832) promyelocytic leukemia
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-PML Antibody, clone 36.1-104, clone 36.1-104, Upstate®, from mouse,
Reactividad de especies
mouse
Aplicación
immunocytochemistry
western blot
western blot
Anti-PML Isoform II Antibody, clone 1A8.1, clone 1A8.1, from mouse,
Reactividad de especies
human
Aplicación
immunocytochemistry
western blot
western blot
Anti-PML Antibody, clone 1F13 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, mouse, rat
Aplicación
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-PML Antibody, clone 2A0N10, Rabbit Monoclonal, ,
Reactividad de especies
human, rat
Aplicación
western blot