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Merck

PIK3CA

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

Sinónimos:
CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha
Especie:
Human PIK3CA (5290), Mouse Pik3ca (18706), Rat Pik3ca (170911), sheep PIK3CA (101110015), chicken PIK3CA (424971), dog PIK3CA (488084), domestic guinea pig Pik3ca (100735084), naked mole-rat Pik3ca (101711934), domestic cat PIK3CA (101097413), cow PIK3CA (282306)
ID UniProtKB:
P42336, Q14CW1, Q99762
ID del gen:
  • Human(5290) Summary: Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. [provided by RefSeq, Jul 2008]
  • Mouse(18706) phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
  • Rat(170911) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • sheep(101110015) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • chicken(424971) phosphoinositide-3-kinase, catalytic, alpha polypeptide
  • dog(488084) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • domestic guinea pig(100735084) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • naked mole-rat(101711934) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • domestic cat(101097413) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • cow(282306) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
AMAB91514
Monoclonal Anti-PIK3CA antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL8347, purified immunoglobulin, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
ZRB1712
Anti-PI-3 kinase p110α Antibody, clone 1J4 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, monkey
Aplicación
affinity binding assay
flow cytometry
immunohistochemistry
western blot
AMAB91513
Monoclonal Anti-PIK3CA antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL8345, purified immunoglobulin, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
western blot
09-481
Anti-PI3 Kinase Antibody, p110α, from rabbit, purified by affinity chromatography,
Reactividad de especies
human, rat
Aplicación
ELISA
immunohistochemistry
immunoprecipitation (IP)
western blot

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
PZ0235
PF-04691502, ≥98% (HPLC),
Especie
human

Kits

Referencia del producto
Descripción
Especie
33-047
Ensayo en 3 etapas de la PI 3-cinasa HTRF®, The PI 3-Kinase 3-Step HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format.,
Especie
human
33-04A
PI 3-Kinase 3-step HTRF® Assay, Everything you need to perform the PI3 Kinase 3-step HTRF assays (1920 wells).,
Especie
human
33-017
PI 3-Kinase HTRF® Assay; 1920 wells, The PI 3-Kinase HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format. This pack size has a screening capacity of 5 plates.,
Especie
human
33-036
PI 3-Kinase HTRF® Assay; 10,000 wells, The PI 3-Kinase HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format. This pack size has a screening capacity of 10,000 wells.,
Especie
human
33-037
PI 3-Kinase HTRF® Assay; 50,000 wells, The PI 3-Kinase HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format. This pack size has a screening capacity of 50,000 wells.,
Especie
human

Proteins

Referencia del producto
Descripción
Especie
14-602-M
PI3 Kinase (p110α/p85α) Protein, active, 20 µg, Active complex of N-terminal His6-tagged recombinant full-length human p110α & untagged, recombinant, full length, human p85α. For use in Kinase Assays.,
Especie
human
14-783-M
PI3 Kinase (p110α(E545K)/p85α), 10 µg, Complex of N-terminal 6His-tagged, recombinant, full-length human p110α containing the mutation E545K & untagged, recombinant, full-length human p85α. For use in Kinase Assays.,
Especie
human
14-790-M
PI3 Kinase (p110α/p65α), 10 µg, Complex of N-terminal 6His-tagged, recombinant, full-length Human p110α & untagged, recombinant, full length Human p65α. For use in Kinase Assays.,
Especie
human
14-787-M
PI3 Kinase (p110α (H1047R)/p85α) Murine, 10 µg, Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α containing the mutation H1047R α & untagged, recombinant, full length mouse p85α. For use in Kinase Assays.,
Especie
mouse
SRP5280
PI3K (p110-α/p85-α), active, His tagged from mouse and human, PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Especie
mouse

esiRNA

Referencia del producto
Descripción
Especie
EHU231281
MISSION® esiRNA, targeting human PIK3CA (2),
Especie
human
EHU039391
MISSION® esiRNA, targeting human PIK3CA,
Especie
human
EMU053821
MISSION® esiRNA, targeting mouse Pik3ca,
Especie
mouse