PDE6A
phosphodiesterase 6A, cGMP-specific, rod, alpha
Sinónimos:
CGPR-A, PDEA, RP43
Especie:
Human PDE6A (5145), Mouse Pde6a (225600), Rat Pde6a (307401), sheep PDE6A (101122024), dog PDE6A (403620), cow PDE6A (281973), domestic guinea pig Pde6a (100725241), Zebrafish pde6a (368410), domestic cat PDE6A (101085100), Domestic Rabbit PDE6A (100342363)
ID UniProtKB:
ID del gen:
- Human(5145) Summary: This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jul 2008]
- Mouse(225600) phosphodiesterase 6A, cGMP-specific, rod, alpha
- Rat(307401) phosphodiesterase 6A, cGMP-specific, rod, alpha
- sheep(101122024) phosphodiesterase 6A, cGMP-specific, rod, alpha
- dog(403620) phosphodiesterase 6A, cGMP-specific, rod, alpha
- cow(281973) phosphodiesterase 6A, cGMP-specific, rod, alpha
- domestic guinea pig(100725241) phosphodiesterase 6A, cGMP-specific, rod, alpha
- Zebrafish(368410) phosphodiesterase 6A, cGMP-specific, rod, alpha
- domestic cat(101085100) phosphodiesterase 6A, cGMP-specific, rod, alpha
- Domestic Rabbit(100342363) phosphodiesterase 6A, cGMP-specific, rod, alpha
- naked mole-rat(101718823) phosphodiesterase 6A, cGMP-specific, rod, alpha
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Antibodies
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Aplicación
Anti-PDE6a Antibody, clone 7A11.1, clone 7A11.1, from mouse,
Reactividad de especies
human
Aplicación
western blot
Small Molecule - Inhibitor
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Dipyridamole for peak identification, European Pharmacopoeia (EP) Reference Standard,
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esiRNA
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