PCDHGA2
protocadherin gamma subfamily A, 2
Sinónimos:
PCDH-GAMMA-A2
Especie:
Human PCDHGA2 (56113), Mouse Pcdhga2 (93710), Rat Pcdhga2 (498846), chicken PCDHGA2 (431363), sheep PCDHGA2 (101104993), domestic cat PCDHGA2 (101097204), cow PCDHGA2 (539654), dog PCDHGA2 (607521), naked mole-rat Pcdhga2 (101707494)
ID UniProtKB:
ID del gen:
- Human(56113) Summary: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
- Mouse(93710) protocadherin gamma subfamily A, 2
- Rat(498846) protocadherin gamma subfamily A, 2
- chicken(431363) protocadherin gamma subfamily A, 2
- sheep(101104993) protocadherin gamma subfamily A, 2
- domestic cat(101097204) protocadherin gamma subfamily A, 2
- cow(539654) protocadherin gamma subfamily A, 2
- dog(607521) protocadherin gamma subfamily A, 2
- naked mole-rat(101707494) protocadherin gamma subfamily A, 2
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