PADI1
peptidyl arginine deiminase, type I
Sinónimos:
HPAD10, PAD1, PDI, PDI1
Especie:
Human PADI1 (29943), Mouse Padi1 (18599), Rat Padi1 (54282), Horse PADI1 (100049961), domestic cat PADI1 (101085557), dog PADI1 (608443), chicken PADI1 (428171), cow PADI1 (618224), naked mole-rat Padi1 (101722077), domestic guinea pig Padi1 (100728246)
ID UniProtKB:
ID del gen:
- Human(29943) Summary: This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]
- Mouse(18599) peptidyl arginine deiminase, type I
- Rat(54282) peptidyl arginine deiminase, type I
- Horse(100049961) peptidyl arginine deiminase, type I
- domestic cat(101085557) peptidyl arginine deiminase, type I
- dog(608443) peptidyl arginine deiminase, type I
- chicken(428171) peptidyl arginine deiminase, type I
- cow(618224) peptidyl arginine deiminase, type I
- naked mole-rat(101722077) peptidyl arginine deiminase, type I
- domestic guinea pig(100728246) peptidyl arginine deiminase, type I
- sheep(101108201) peptidyl arginine deiminase, type I
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