MPZL2
myelin protein zero-like 2
Sinónimos:
EVA, EVA1
Especie:
Human MPZL2 (10205), Mouse Mpzl2 (14012), Rat Mpzl2 (300679), chicken MPZL2 (419779), dog MPZL2 (489384), domestic cat MPZL2 (101089039), naked mole-rat Mpzl2 (101711086), domestic guinea pig Mpzl2 (100728058), sheep MPZL2 (101122302), cow MPZL2 (540423)
ID UniProtKB:
ID del gen:
- Human(10205) Summary: Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(14012) myelin protein zero-like 2
- Rat(300679) myelin protein zero-like 2
- chicken(419779) myelin protein zero-like 2
- dog(489384) myelin protein zero-like 2
- domestic cat(101089039) myelin protein zero-like 2
- naked mole-rat(101711086) myelin protein zero-like 2
- domestic guinea pig(100728058) myelin protein zero-like 2
- sheep(101122302) myelin protein zero-like 2
- cow(540423) myelin protein zero-like 2
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