Saltar al contenido
Merck

MMP8

matrix metallopeptidase 8 (neutrophil collagenase)

Sinónimos:
CLG1, HNC, MMP-8, PMNL-CL
Especie:
ID UniProtKB:
ID del gen:
  • Human(4317) Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
  • Mouse(17394) matrix metallopeptidase 8
  • Rat(63849) matrix metallopeptidase 8
  • domestic guinea pig(100724670) matrix metallopeptidase 8 (neutrophil collagenase)
  • naked mole-rat(101716969) matrix metallopeptidase 8 (neutrophil collagenase)
  • sheep(101120601) matrix metallopeptidase 8 (neutrophil collagenase)
  • domestic cat(101080995) matrix metallopeptidase 8 (neutrophil collagenase)
  • Horse(100069005) matrix metallopeptidase 8 (neutrophil collagenase)
  • cow(100336575) matrix metallopeptidase 8 (neutrophil collagenase)
  • dog(489429) matrix metallopeptidase 8 (neutrophil collagenase)

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-Mmp8 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
Doxycycline monohydrate, ,
Especie
human
Doxycycline Monohydrate, United States Pharmacopeia (USP) Reference Standard,
Especie
human
α-Sexithiophene, ,
Especie
human, rat
Marimastat, ≥98% (HPLC),
Especie
human, rat, mouse
CP-101537, ≥98% (HPLC),
Especie
human, rat, mouse

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting human MMP8,
Especie
human