MDM4
Mdm4 p53 binding protein homolog (mouse)
Sinónimos:
HDMX, MDMX, MRP1
Especie:
Human MDM4 (4194), Mouse Mdm4 (17248), Rat Mdm4 (304798), domestic guinea pig Mdm4 (100719525), naked mole-rat Mdm4 (101720853), Horse MDM4 (100050113), sheep MDM4 (101112914), Domestic Rabbit MDM4 (100351683), dog MDM4 (478939), domestic cat MDM4 (101082460) ...Más
ID UniProtKB:
ID del gen:
- Human(4194) Summary: This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
- Mouse(17248) transformed mouse 3T3 cell double minute 4
- Rat(304798) Mdm4 p53 binding protein homolog (mouse)
- domestic guinea pig(100719525) Mdm4 p53 binding protein homolog (mouse)
- naked mole-rat(101720853) Mdm4 p53 binding protein homolog (mouse)
- Horse(100050113) Mdm4 p53 binding protein homolog (mouse)
- sheep(101112914) Mdm4 p53 binding protein homolog (mouse)
- Domestic Rabbit(100351683) Mdm4 p53 binding protein homolog (mouse)
- dog(478939) Mdm4 p53 binding protein homolog (mouse)
- domestic cat(101082460) Mdm4 p53 binding protein homolog (mouse)
- chicken(419823) Mdm4 p53 binding protein homolog (mouse)
- Zebrafish(334932) transformed 3T3 cell double minute 4 homolog (mouse)
- cow(514225) Mdm4 p53 binding protein homolog (mouse)
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anticuerpo anti-Mdmx, clon 8C6, clone 8C6, from mouse,
Reactividad de especies
human
Aplicación
ChIP
flow cytometry
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-MDM4 Antibody, clone 7A8, clone 7A8, from mouse,
Reactividad de especies
human, mouse
Aplicación
western blot