MAP3K3
mitogen-activated protein kinase kinase kinase 3
Sinónimos:
MAPKKK3, MEKK3
Especie:
Human MAP3K3 (4215), Mouse Map3k3 (26406), Rat Map3k3 (303604), cow MAP3K3 (508943), Horse MAP3K3 (100064751), naked mole-rat Map3k3 (101704335), domestic guinea pig Map3k3 (100731994), sheep MAP3K3 (101122537), domestic cat MAP3K3 (101083633), dog MAP3K3 (480481) ...Más
ID UniProtKB:
ID del gen:
- Human(4215) Summary: This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
- Mouse(26406) mitogen-activated protein kinase kinase kinase 3
- Rat(303604) mitogen activated protein kinase kinase kinase 3
- cow(508943) mitogen-activated protein kinase kinase kinase 3
- Horse(100064751) mitogen-activated protein kinase kinase kinase 3
- naked mole-rat(101704335) mitogen-activated protein kinase kinase kinase 3
- domestic guinea pig(100731994) mitogen-activated protein kinase kinase kinase 3
- sheep(101122537) mitogen-activated protein kinase kinase kinase 3
- domestic cat(101083633) mitogen-activated protein kinase kinase kinase 3
- dog(480481) mitogen-activated protein kinase kinase kinase 3
- chicken(419954) mitogen-activated protein kinase kinase kinase 3
- Zebrafish(560211) mitogen-activated protein kinase kinase kinase 3
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-Map3K3 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
Anti-MEKK3 Antibody, clone 9N3Y9, Rabbit Monoclonal, ,
Reactividad de especies
mouse
Aplicación
western blot