LITAF
lipopolysaccharide-induced TNF factor
Sinónimos:
PIG7, SIMPLE, TP53I7
Especie:
Human LITAF (9516), Mouse Litaf (56722), Rat Litaf (65161), chicken LITAF (374125), Zebrafish litaf (431731), dog LITAF (490004), domestic cat LITAF (101083562), cow LITAF (520564), sheep LITAF (101109408), domestic guinea pig Litaf (100729493) ...Más
ID UniProtKB:
ID del gen:
- Human(9516) Summary: Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2008]
- Mouse(56722) LPS-induced TN factor
- Rat(65161) lipopolysaccharide-induced TNF factor
- chicken(374125) lipopolysaccharide-induced TNF factor
- Zebrafish(431731) lipopolysaccharide-induced TNF factor
- dog(490004) lipopolysaccharide-induced TNF factor
- domestic cat(101083562) lipopolysaccharide-induced TNF factor
- cow(520564) lipopolysaccharide-induced TNF factor
- sheep(101109408) lipopolysaccharide-induced TNF factor
- domestic guinea pig(100729493) lipopolysaccharide-induced TNF factor
- naked mole-rat(101725320) lipopolysaccharide-induced TNF factor
- Horse(100033923) lipopolysaccharide-induced TNF factor
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