KCNJ11
potassium inwardly-rectifying channel, subfamily J, member 11
Sinónimos:
BIR, HHF2, IKATP, KIR6.2, PHHI, TNDM3
Especie:
Human KCNJ11 (3767), Mouse Kcnj11 (16514), Rat Kcnj11 (83535), domestic cat KCNJ11 (101097019), sheep KCNJ11 (101114135), Horse KCNJ11 (100056520), Zebrafish kcnj11 (664687), Domestic Rabbit KCNJ11 (100008648), naked mole-rat Kcnj11 (101705172), dog KCNJ11 (485401) ...Más
ID UniProtKB:
ID del gen:
- Human(3767) Summary: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009]
- Mouse(16514) potassium inwardly rectifying channel, subfamily J, member 11
- Rat(83535) potassium inwardly rectifying channel, subfamily J, member 11
- domestic cat(101097019) potassium inwardly-rectifying channel, subfamily J, member 11
- sheep(101114135) potassium inwardly-rectifying channel, subfamily J, member 11
- Horse(100056520) potassium inwardly-rectifying channel, subfamily J, member 11
- Zebrafish(664687) potassium inwardly-rectifying channel, subfamily J, member 11
- Domestic Rabbit(100008648) potassium inwardly-rectifying channel, subfamily J, member 11
- naked mole-rat(101705172) potassium inwardly-rectifying channel, subfamily J, member 11
- dog(485401) potassium inwardly-rectifying channel, subfamily J, member 11
- chicken(428846) potassium inwardly-rectifying channel, subfamily J, member 11
- cow(532060) potassium inwardly-rectifying channel, subfamily J, member 11
- domestic guinea pig(100135564) potassium inwardly rectifying channel, subfamily J, member 11
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Small Molecule - Antagonist
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Antibodies
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Reactividad de especies
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Anti-Potassium Channel Kir6.2 Antibody, clone 10C1.1, clone 10C1.1, from mouse,
Reactividad de especies
human, rat
Aplicación
western blot
Small Molecule - Blocker
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Glyburide (Glibenclamide), Pharmaceutical Secondary Standard; Certified Reference Material,
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human
Small Molecule - Opener
esiRNA
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