HEXB
hexosaminidase B (beta polypeptide)
Sinónimos:
ENC-1AS
Especie:
Human HEXB (3074), Mouse Hexb (15212), Rat Hexb (294673), naked mole-rat Hexb (101713145), chicken HEXB (427204), dog HEXB (478100), domestic cat HEXB (493928), sheep HEXB (101111906), cow HEXB (618571), Domestic Rabbit HEXB (100009508)
ID UniProtKB:
ID del gen:
- Human(3074) Summary: Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). [provided by RefSeq, Jul 2008]
- Mouse(15212) hexosaminidase B
- Rat(294673) hexosaminidase B
- naked mole-rat(101713145) hexosaminidase B (beta polypeptide)
- chicken(427204) hexosaminidase B (beta polypeptide)
- dog(478100) hexosaminidase B (beta polypeptide)
- domestic cat(493928) hexosaminidase B (beta polypeptide)
- sheep(101111906) hexosaminidase B (beta polypeptide)
- cow(618571) hexosaminidase B (beta polypeptide)
- Domestic Rabbit(100009508) hexosaminidase B (beta polypeptide)
- domestic guinea pig(100731613) hexosaminidase B (beta polypeptide)
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