GRN
granulin
Sinónimos:
CLN11, GEP, GP88, PCDGF, PEPI, PGRN
Especie:
Human GRN (2896), Mouse Grn (14824), Rat Grn (29143), fruit fly grn (40962), dog GRN (480501), Horse GRN (100051035), domestic cat GRN (101100680), cow GRN (767942), sheep GRN (101115470), Domestic Rabbit GRN (100349528) ...Más
ID UniProtKB:
ID del gen:
- Human(2896) Summary: Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
- Mouse(14824) granulin
- Rat(29143) granulin
- fruit fly(40962) grain
- dog(480501) granulin
- Horse(100051035) granulin
- domestic cat(101100680) granulin
- cow(767942) granulin
- sheep(101115470) granulin
- Domestic Rabbit(100349528) granulin
- domestic guinea pig(100135533) granulin
- naked mole-rat(101715753) granulin
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-Progranulin/GRN Antibody, clone 8H10, clone 8H10, from rat,
Reactividad de especies
mouse
Aplicación
immunohistochemistry
western blot
western blot
Anti-Granulin Antibody, clone 8O5Q5, Rabbit Monoclonal, ,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
western blot
western blot