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Merck

GRM7

glutamate receptor, metabotropic 7

Sinónimos:
GLUR7, GPRC1G, MGLU7, MGLUR7
Especie:
ID UniProtKB:
ID del gen:
  • Human(2917) Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
  • Mouse(108073) glutamate receptor, metabotropic 7
  • Rat(81672) glutamate receptor, metabotropic 7
  • Zebrafish(564461) glutamate receptor, metabotropic 7
  • chicken(416112) glutamate receptor, metabotropic 7
  • Horse(100052696) glutamate receptor, metabotropic 7
  • domestic cat(101090088) glutamate receptor, metabotropic 7
  • Domestic Rabbit(100343810) glutamate receptor, metabotropic 7
  • cow(535362) glutamate receptor, metabotropic 7
  • dog(484674) glutamate receptor, metabotropic 7

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Small Molecule - Agonist

Referencia del producto
Descripción
Especie
O-Phospho-L-serine, ,
Especie
human
trans-(±)-ACPD monohydrate, solid, ≥97% (NMR),
Especie
human
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Especie
rat, human
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Especie
rat, human
L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Especie
rat, human

Small Molecule - Antagonist

Referencia del producto
Descripción
Especie
DL-2-Amino-3-phosphonopropionic acid, ,
Especie
human
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Especie
rat, human
L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Especie
rat, human
L-Glutamic acid, BioUltra, ≥99.5% (NT),
Especie
rat, human
L-Glutamic acid, FCC,
Especie
rat, human

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anticuerpo anti-mGluR7, Upstate®, from rabbit,
Reactividad de especies
rat
Aplicación
western blot
Anti-Metabotropic Glutamate Receptor 7 Antibody, Chemicon®, from rabbit,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot

Small Molecule - Mixed Agonist/Antagonist

Referencia del producto
Descripción
Especie
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Especie
rat, human
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Especie
rat, human
L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Especie
rat, human
L-Glutamic acid, BioUltra, ≥99.5% (NT),
Especie
rat, human
L-Glutamic acid, FCC,
Especie
rat, human

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting mouse Ak032068,
Especie
mouse
MISSION® esiRNA, targeting human GRM7,
Especie
human