GNE
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Sinónimos:
DMRV, GLCNE, IBM2, NM, Uae1
Especie:
Human GNE (10020), Mouse Gne (50798), Rat Gne (114711), Zebrafish gne (393857), chicken GNE (427285), dog GNE (481607), Horse GNE (100067216), domestic cat GNE (101098411), sheep GNE (101110735), cow GNE (782201) ...Más
ID UniProtKB:
ID del gen:
- Human(10020) Summary: The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- Mouse(50798) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
- Rat(114711) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
- Zebrafish(393857) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
- chicken(427285) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
- dog(481607) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
- Horse(100067216) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
- domestic cat(101098411) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
- sheep(101110735) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
- cow(782201) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
- Domestic Rabbit(100340455) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
- naked mole-rat(101705910) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
- domestic guinea pig(100731383) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
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