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Merck

CYP2C19

cytochrome P450, family 2, subfamily C, polypeptide 19

Sinónimos:
CPCJ, CYP2C, P450C2C, P450IIC19
Especie:
Human CYP2C19 (1557), sheep CYP2C19 (100534653), cow CYP2C19 (510380)
ID UniProtKB:
P33261, P33259, Q8WZB1, Q8WZB2, Q9UCD4
ID del gen:
  • Human(1557) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]
  • sheep(100534653) cytochrome P450 2C19
  • cow(510380) cytochrome P450, family 2, subfamily C, polypeptide 19

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Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
S0758
Sulfaphenazole, ≥98%,
Especie
human
B5774
Benzbromarone, analytical standard,
Especie
human
S8307
SB 203580, solid, ≥98% (HPLC),
Especie
human

Proteins

Referencia del producto
Descripción
Especie
MTOXCE2C19
CypExpress™ 2C19 Cytochrome P450 human, ,
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
EHU127101
MISSION® esiRNA, targeting human CYP2C19,
Especie
human