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Merck

CYP11B1

cytochrome P450, family 11, subfamily B, polypeptide 1

Sinónimos:
CPN1, CYP11B, FHI, P450C11
Especie:
Human CYP11B1 (1584), Mouse Cyp11b1 (110115), Rat Cyp11b1 (500892), sheep CYP11B1 (767576), cow CYP11B1 (282422), domestic guinea pig Cyp11b1 (100135511)
ID UniProtKB:
P15538, Q14095, Q4VAQ8, Q4VAQ9, Q9UML2
ID del gen:
  • Human(1584) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(110115) cytochrome P450, family 11, subfamily b, polypeptide 1
  • Rat(500892) cytochrome P450, family 11, subfamily b, polypeptide 1
  • sheep(767576) cytochrome P450, family 11, subfamily B, polypeptide 1
  • cow(282422) cytochrome P450, subfamily XI B, polypeptide 1
  • domestic guinea pig(100135511) cytochrome P450, family 11, subfamily b, polypeptide 1

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
ZRB2564
Anti-CYP11B1 Antibody, clone 1J14 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, monkey
Aplicación
affinity binding assay
immunofluorescence
immunohistochemistry
western blot
MABS502
Anti-CYP11B1 Antibody, clone 80-7, clone 80-7, from rat,
Reactividad de especies
human, rat
Aplicación
immunohistochemistry
western blot
MAB6020
Anti-Cytochrome P450 11β-Hydroxylase Antibody, clone 11B2-1A4, culture supernatant, clone 11B2-1A4, Chemicon®,
Reactividad de especies
rat
Aplicación
immunohistochemistry
western blot

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
35485
2,4′-DDD, PESTANAL®, analytical standard,
Especie
human
1445007
1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane, United States Pharmacopeia (USP) Reference Standard,
Especie
human
44012
1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland,
Especie
human
K1003
Ketoconazole, 99.0-101.0% (EP, titration),
Especie
mouse, human, rat
UC280
Ketoconazole, ,
Especie
mouse, human, rat

esiRNA

Referencia del producto
Descripción
Especie
EHU140441
MISSION® esiRNA, targeting human CYP11B1,
Especie
human