CIITA
class II, major histocompatibility complex, transactivator
Sinónimos:
C2TA, CIITAIV, MHC2TA, NLRA
Especie:
Human CIITA (4261), Mouse Ciita (12265), Rat Ciita (85483), Zebrafish ciita (100003537), chicken CIITA (427676), dog CIITA (490008), sheep CIITA (101106564), domestic guinea pig Ciita (100726338), Horse CIITA (100056546), Domestic Rabbit CIITA (100338894) ...Más
ID UniProtKB:
ID del gen:
- Human(4261) Summary: This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the 'master control factor' for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq, Jul 2008]
- Mouse(12265) class II transactivator
- Rat(85483) class II, major histocompatibility complex, transactivator
- Zebrafish(100003537) class II, major histocompatibility complex, transactivator
- chicken(427676) class II, major histocompatibility complex, transactivator
- dog(490008) class II, major histocompatibility complex, transactivator
- sheep(101106564) class II, major histocompatibility complex, transactivator
- domestic guinea pig(100726338) class II, major histocompatibility complex, transactivator
- Horse(100056546) class II, major histocompatibility complex, transactivator
- Domestic Rabbit(100338894) class II, major histocompatibility complex, transactivator
- naked mole-rat(101721690) class II, major histocompatibility complex, transactivator
- cow(508720) class II, major histocompatibility complex, transactivator
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-CIITA antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
Anti-CIITA Antibody, from rabbit, purified by affinity chromatography,
Reactividad de especies
human, mouse
Aplicación
immunohistochemistry
western blot
western blot