CCNE1
cyclin E1
Sinónimos:
CCNE
Especie:
Human CCNE1 (898), Mouse Ccne1 (12447), Rat Ccne1 (25729), naked mole-rat Ccne1 (101711961), Horse CCNE1 (100053882), chicken CCNE1 (426117), Zebrafish ccne1 (30188), dog CCNE1 (484610), cow CCNE1 (533526), domestic cat CCNE1 (101086192) ...Más
ID UniProtKB:
ID del gen:
- Human(898) Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq, Jul 2008]
- Mouse(12447) cyclin E1
- Rat(25729) cyclin E1
- naked mole-rat(101711961) cyclin E1
- Horse(100053882) cyclin E1
- chicken(426117) cyclin E1
- Zebrafish(30188) cyclin E1
- dog(484610) cyclin E1
- cow(533526) cyclin E1
- domestic cat(101086192) cyclin E1
- sheep(101107124) cyclin E1
- Domestic Rabbit(100134864) cyclin E1
- domestic guinea pig(100727568) cyclin E1
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-Cyclin E Antibody, clone 1C7 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human
Aplicación
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anticuerpo anti-ciclina E, clon HE12, clone HE12, Upstate®, from mouse,
Reactividad de especies
human
Aplicación
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-Cyclin E Antibody, Upstate®, from rabbit,
Reactividad de especies
mouse, rat
Aplicación
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-Cyclin E1 Antibody, clone 1L1W8, Rabbit Monoclonal, ,
Reactividad de especies
human, rat
Aplicación
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Phospho-Cyclin E1-T77 antibody produced in rabbit, ,
Reactividad de especies
human
Aplicación
western blot
Proteins
Referencia del producto
Descripción
Especie
Cdk2/Cyclin E Protein, active, 10 µg, Active complex of recombinant full length human Cdk2 containing a C-terminal His6-tag & recombinant full-length human Cyclin E containing an N-terminal GST-tag. For use in Kinase Assays.,
Especie
human