CBL
Cbl proto-oncogene, E3 ubiquitin protein ligase
Sinónimos:
C-CBL, CBL2, FRA11B, NSLL, RNF55
Especie:
Human CBL (867), Mouse Cbl (12402), Rat Cbl (500985), Thale Cress CBL (824872), chicken CBL (374038), Zebrafish cbl (492364), fruit fly Cbl (38961), dog CBL (489369), sheep CBL (101115401), cow CBL (527418) ...Más
ID UniProtKB:
ID del gen:
- Human(867) Summary: This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012]
- Mouse(12402) Casitas B-lineage lymphoma
- Rat(500985) Cbl proto-oncogene, E3 ubiquitin protein ligase
- Thale Cress(824872) cystathionine beta-lyase
- chicken(374038) Cbl proto-oncogene, E3 ubiquitin protein ligase
- Zebrafish(492364) Cas-Br-M (murine) ecotropic retroviral transforming sequence
- fruit fly(38961) CG7037 gene product from transcript CG7037-RB
- dog(489369) Cbl proto-oncogene, E3 ubiquitin protein ligase
- sheep(101115401) Cbl proto-oncogene, E3 ubiquitin protein ligase
- cow(527418) Cbl proto-oncogene, E3 ubiquitin protein ligase
- Horse(100071403) Cbl proto-oncogene, E3 ubiquitin protein ligase
- domestic cat(101096508) Cbl proto-oncogene, E3 ubiquitin protein ligase
- Domestic Rabbit(100342595) Cbl proto-oncogene, E3 ubiquitin protein ligase
- naked mole-rat(101710004) Cbl proto-oncogene, E3 ubiquitin protein ligase
- domestic guinea pig(100725041) Cbl proto-oncogene, E3 ubiquitin protein ligase
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-Cbl Antibody, clone 7G10, clone 7G10, Upstate®, from mouse,
Reactividad de especies
human, mouse, rat
Aplicación
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot