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Merck

ATP1A1

ATPase, Na+/K+ transporting, alpha 1 polypeptide

Sinónimos:
Especie:
ID UniProtKB:
ID del gen:
  • Human(476) Summary: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
  • Mouse(11928) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • Rat(24211) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • domestic cat(101083695) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • Horse(100034139) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • dog(403992) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • chicken(396530) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • Domestic Rabbit(100302415) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • sheep(443381) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • cow(282144) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • naked mole-rat(101697634) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • domestic guinea pig(100192382) ATPase, Na+/K+ transporting, alpha 1 polypeptide

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Small Molecule - Activator

Referencia del producto
Descripción
Especie
Digitoxigenin, ,
Especie
rat

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
xenopus, canine, human, monkey, mouse, porcine, rabbit, rat, sheep
Aplicación
immunocytochemistry
immunohistochemistry

western blot
Anti-Na+/K+ ATPase alpha-3, from rabbit,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
western blot
Anti-Na+/K+ ATPase α-1 Antibody, Upstate®, from rabbit,
Reactividad de especies
bovine, human, rat
Aplicación
immunocytochemistry
immunoprecipitation (IP)

western blot
Anti-ATP1A1 (N-terminal) antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human
Aplicación
western blot
Anti-Na+/K+-ATPase antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
western blot

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
Melittin, ≥97% (HPLC), synthetic,
Especie
mouse, rat, human
Digitoxin, ≥92% (HPLC), powder,
Especie
human
Digoxin, United States Pharmacopeia (USP) Reference Standard,
Especie
human
Digitoxin, United States Pharmacopeia (USP) Reference Standard,
Especie
human
Digoxin, analytical standard,
Especie
human

Proteins

Referencia del producto
Descripción
Especie
Adenosine 5′-Triphosphatase from porcine cerebral cortex, lyophilized powder, ≥0.3 units/mg protein, pH 7.8,
Especie

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting human ATP1A1,
Especie
human
MISSION® esiRNA, targeting mouse Atp1a1,
Especie
mouse