APLP2
amyloid beta (A4) precursor-like protein 2
Sinónimos:
APLP-2, APPH, APPL2, CDEBP
Especie:
Human APLP2 (334), Mouse Aplp2 (11804), Rat Aplp2 (64312), naked mole-rat Aplp2 (101696833), Horse APLP2 (100068170), Horse APLP2 (100072668), domestic cat APLP2 (101095518), sheep APLP2 (101119774), domestic guinea pig Aplp2 (100713756), Domestic Rabbit APLP2 (100358231) ...Más
ID UniProtKB:
ID del gen:
- Human(334) Summary: This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
- Mouse(11804) amyloid beta (A4) precursor-like protein 2
- Rat(64312) amyloid beta (A4) precursor-like protein 2
- naked mole-rat(101696833) amyloid beta (A4) precursor-like protein 2
- Horse(100068170) amyloid beta (A4) precursor-like protein 2
- Horse(100072668) amyloid beta (A4) precursor-like protein 2
- domestic cat(101095518) amyloid beta (A4) precursor-like protein 2
- sheep(101119774) amyloid beta (A4) precursor-like protein 2
- domestic guinea pig(100713756) amyloid beta (A4) precursor-like protein 2
- Domestic Rabbit(100358231) amyloid beta (A4) precursor-like protein 2
- chicken(419727) amyloid beta (A4) precursor-like protein 2
- Zebrafish(796801) amyloid beta (A4) precursor-like protein 2
- cow(785005) amyloid beta (A4) precursor-like protein 2
- dog(479393) amyloid beta (A4) precursor-like protein 2
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