Turn Options Into Opportunities
Immerse yourself in an exciting world of infinite choices.
Empowering you to make confident, well-informed decisions for your PHARMACEUTICAL DEVELOPMENT AND manufacturing
You need to make complex decisions for your drug development and manufacturing. Discover our products and technologies in the navigation section below and turn options into opportunities to solve your toughest pharma and biopharma challenges – from cell culture to purification and formulation.
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Explore our Products & Services for mAbs, mRNA-based Drugs, Viral Vector Therapies, and Small Molecules
mAb Development and Manufacturing
You need efficient processes that deliver high-quality monoclonal antibodies (mAbs). Our process intensification strategies empower you to make informed decisions to increase productivity and set the course for Biopharma 4.0.
Upstream Intensification
Explore future-proof manufacturing strategies to increase upstream productivity.
Downstream Intensification
Find options to purify intensified feed streams faster while meeting drug substance release criteria.
Biopharmaceutical Formulation
Choose from best-practice strategies for mastering your formulation challenges with confidence.
pDNA and mRNA Development and Manufacturing
The development and production of plasmid DNA (pDNA) and mRNA require important considerations regarding process efficiency and product stability. Find the options and advanced technologies you need to set up a streamlined, efficient process for your pDNA and mRNA manufacturing – and manage it with confidence.
mRNA Manufacturing Proven Template
Explore our integrated offering – empowering you to unlock the potential of mRNA based therapeutics.
pDNA Purification
Navigate a straight path in pDNA purification, choosing the right products and chemicals.
Viral Vector Development and Manufacturing
Viral vector manufacturing at the required speed, scale, and safety poses challenges – especially in an evolving regulatory landscape. Proven options for viral vector production, DNA digestion, cell lysis, and adeno-associated viruses (AAV) empty-full separation, empower you to navigate your individual path for efficient process development and virus production.
Viral Vector Upstream Platforms
Speed up your AAV and lentiviral vector production and unlock your gene therapy’s potential.
DNA Digestion
Set your AAV free with effective cell lysis and DNA digestion, and boost AAV titers and infectivity.
AAV Empty-Full Separation
Optimize gene therapy with our strategies for separating empty and full capsids effectively.
Small Molecules Development and Manufacturing
API stability, release kinetics, solubility, and bioavailability limitations are critical obstacles on the path to market. Choose from a wide portfolio of high-quality pharmaceutical raw materials and active pharmaceutical ingredients (APIs) as well as effective and tailor-made functional excipients to master your formulation challenges.
Pediatric Formulations
Make confident decisions to meet the complex needs of pediatric pharmaceutical formulations.
Oral Solid Dose Formulation
Explore our broad portfolio of excipients to master the challenges of oral solid dose manufacturing.
Functional Excipients for Tableting Technologies
Discover functional excipients empowering you to overcome critical obstacles in tableting.
Parenteral Formulation
Mitigate risk and improve patient safety by relying on high-quality, low-in-endotoxin excipients.
Enter an exciting world of infinite choices for your drug development and manufacturing
Explore our Millipore® and SAFC® portfolios to access an exciting world full of options to solve your most urgent pharma and biopharma challenges like process intensification, digital transformation, high-concentration therapeutics, process templates for new modalities, or support to help navigate evolving regulatory requirements. With a wide portfolio of cutting-edge products, services, and regulatory consultancy, we can help streamline your decision-making and support your drug development journey as you move confidently and quickly through process development and larger-scale GMP production.
Related Resources
- Article: Seed Train Intensification Using High Cell Density Cryopreservation
This article explains the benefits of high cell density cryopreservation (HCDC) and how to implement it.
- Article: Cell Retention Technology and Specialized Cell Culture Media for Intensified Upstream Processing
This study demonstrates the use of a Cellicon® filter and controller in an N-1 perfusion process with Cellvento® 4CHO-X expansion medium as compared to a control seed train using shake flasks.
- Article: Accelerate Perfusion Media Development and Predict Large-Scale Processes using a Single-use, Automated Microbioreactor
This page describes the use of a small-scale perfusion bioreactor with integrated microfluidic flow control and sensor technologies to predict large-scale processes.
- Article: Plasmid DNA Purification Process
Free eBook outlines plasmid DNA manufacturing process and downstream purification challenges for various applications.
- Article: Cell and Gene Therapy Manufacturing: Upstream Processing for AAV and Lentivirus Platforms
This technical article will provide a high-level overview of cell and gene therapy production, with a focus on the upstream cell culture production of viral vectors.
- Article: Scalability and Performance of Mobius® iFlex Bioreactors
This page summarizes several performance attributes and scalability data for Mobius® iFlex Bioreactors, single-use, stirred tank systems designed to support traditional and intensified fed-batch and perfusion cell culture applications.
- Article: mRNA Process & Cost Modeling: Optimize Development
A cost-model compares modalities like viral vectors and mRNA for production scale decision-making.
- Article: Solid Formulation Development Using Melt-based 3D Printing Technologies
3D printing can overcome challenges during formulation development, with a focus on enhancing API bioavailability in solid dispersions. Find out how in this technical article.
- Article: One-Batch Calibration: A Process-, Instrument-, Scale- & Site-agnostic Method For Streamlining Raman Implementation
Challenges associated with Raman spectroscopy implementation in bioprocesses can be overcome by the innovative one-batch calibration approach. This streamlined process requires less time and resources compared to traditional approaches, unlocking Raman benefits for biopharmaceutical applications.
- Article: In-line Real-time Monitoring of CHO Cell Culture Process Parameters Using Raman Spectroscopy
Cell culture processes are complex and highly variable and yet only a handful of key parameters such as temperature, pH, and dissolved oxygen (DO) are typically controlled in real time.
Related Videos
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You need to make complex decisions to get your drug to market knowing that any decision you take now may be difficult to change later or will require significant backtracking and resources to revise.
With the right raw materials, products, services, and guidance designed for pharma and biopharma manufacturing, we can help you make the right decisions to improve process economics, accelerate time to market, and mitigate production risks.
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