- Orchestrating Role of Apoptosis Inhibitor of Macrophage in the Resolution of Acute Lung Injury.
Orchestrating Role of Apoptosis Inhibitor of Macrophage in the Resolution of Acute Lung Injury.
Journal of immunology (Baltimore, Md. : 1950) (2017-10-27)
Hiroki Kimura, Masaru Suzuki, Satoshi Konno, Hideo Shindou, Takao Shimizu, Takahide Nagase, Toru Miyazaki, Masaharu Nishimura
PMID29070674
ABSTRACT
Appropriate resolution of inflammation is known to be essential in tissue homeostasis. In this study, we evaluated the significance of a macrophage-derived soluble protein, apoptosis inhibitor of macrophage (AIM), in LPS-induced lung injury in mice. After oropharyngeal administration of LPS, the level of free-form serum AIM increased on days 2-4, accompanied by the resolution of inflammation, which was observed in the cellular profile of bronchoalveolar lavage fluid. In an experiment using wild-type (WT) and
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