- Cap-independent translation ensures mTOR expression and function upon protein synthesis inhibition.
Cap-independent translation ensures mTOR expression and function upon protein synthesis inhibition.
RNA (New York, N.Y.) (2017-08-20)
Ana Marques-Ramos, Marco M Candeias, Juliane Menezes, Rafaela Lacerda, Margaret Willcocks, Alexandre Teixeira, Nicolas Locker, Luísa Romão
PMID28821580
ABSTRACT
The mechanistic/mammalian target of rapamycin (mTOR) is a conserved serine/threonine kinase that integrates cellular signals from the nutrient and energy status to act, namely, on the protein synthesis machinery. While major advances have emerged regarding the regulators and effects of the mTOR signaling pathway, little is known about the regulation of
MATERIALS