- CCN3 promotes epithelial-mesenchymal transition in prostate cancer via FAK/Akt/HIF-1α-induced twist expression.
CCN3 promotes epithelial-mesenchymal transition in prostate cancer via FAK/Akt/HIF-1α-induced twist expression.
Oncotarget (2017-11-02)
Po-Chun Chen, Huai-Ching Tai, Tien-Huang Lin, Shih-Wei Wang, Chih-Yang Lin, Chia-Chia Chao, Hong-Jeng Yu, Yu-Chieh Tsai, Yu-Wei Lai, Chiao-Wen Lin, Chih-Hsin Tang
PMID29088803
ABSTRACT
Epithelial-mesenchymal transition (EMT) has received considerable attention as a conceptual paradigm for explaining metastatic behavior during cancer progression. NOV/CCN3 is a matrix-associated protein involved in many cellular functions. Previous studies have shown that CCN3 expression is upregulated in prostate cancer (PCa) cells and in PCa patients. In this study, we have provided evidence of tumor promoting effects of CCN3, which includes induction of epithelial-to-mesenchymal transition (EMT) and tumor metastasis. We used an orthotopic
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