Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Dalton transactions (Cambridge, England : 2003) (2013-03-27)

George Psomas, Dimitris P Kessissoglou

ABSTRACT

The structural features of copper(II), nickel(II), cobalt(II) and zinc(II) complexes with the antimicrobial drugs quinolones and non-steroidal anti-inflammatory drugs (NSAIDs) as ligands are discussed. The binding properties of these complexes to biomolecules (calf-thymus DNA, bovine or human serum albumin) are presented and evaluated. The biological activity (antimicrobial, antioxidant and antiproliferative) of selected complexes is investigated. Further perspectives concerning the synthesis and the biological activity of novel complexes with quinolones or NSAIDs attractive to synthetic chemists, biochemists and/or biologists are presented.

MATERIALS

Product Number

Brand

Product Description

266655

Sigma-Aldrich

Cobalt, pieces, 99.5% trace metals basis

697745

Sigma-Aldrich

Cobalt, Carbon coated magnetic, nanopowder, <50 nm particle size (TEM), ≥99%

203076

Sigma-Aldrich

Cobalt, granular, 99.99% trace metals basis

398810

Sigma-Aldrich

Cobalt, rod, diam. 5.0 mm, 99.95% trace metals basis

266647

Sigma-Aldrich

Cobalt, powder, <150 μm, ≥99.9% trace metals basis

267074

Sigma-Aldrich

Nickel, rod, diam. 6.35 mm, ≥99.99% trace metals basis

357553

Sigma-Aldrich

Nickel, foil, thickness 0.5 mm, 99.98% trace metals basis

266981

Sigma-Aldrich

Nickel, powder, <50 μm, 99.7% trace metals basis

357626

Sigma-Aldrich

Nickel, wire, diam. 0.5 mm, ≥99.9% trace metals basis

326380

Sigma-Aldrich

Cobalt, foil, thickness 0.1 mm, ≥99.99%

356867

Sigma-Aldrich

Cobalt, foil, thickness 0.1 mm, 99.95% trace metals basis

356891

Sigma-Aldrich

Cobalt, foil, thickness 1.0 mm, 99.95% trace metals basis

266639

Sigma-Aldrich

Cobalt, powder, 2 μm particle size, 99.8% trace metals basis

577995

Sigma-Aldrich

Nickel, nanopowder, <100 nm avg. part. size, ≥99% trace metals basis

357588

Sigma-Aldrich

Nickel, foil, thickness 0.1 mm, 99.98% trace metals basis

266701

Sigma-Aldrich

Cobalt, wire, diam. 1.0 mm, 99.995% trace metals basis

GF51036454

Nickel, foil, light tested, 100x100mm, thickness 0.075mm, annealed, 99%

GF55176903

Nickel, foil, not light tested, 100x100mm, thickness 0.0125mm, annealed, 99%

GF46146113

Nickel, foil, light tested, 50x50mm, thickness 0.03mm, 99.9%

GF55760799

Nickel, foil, light tested, 150x150mm, thickness 0.0125mm, annealed, 99%

GF83452204

Nickel, foil, light tested, 100x100mm, thickness 0.01mm, 99.95%

GF62490843

Nickel, foil, light tested, 50x50mm, thickness 0.05mm, annealed, 99%

GF88121943

Nickel, foil, light tested, 25x25mm, thickness 0.025mm, annealed, 99%

GF14847453

Nickel, foil, 25mm disks, thickness 0.25mm, annealed, 99%

GF90427136

Nickel, foil, not light tested, 150x150mm, thickness 0.0125mm, 99.9%

GF27481732

Cobalt, foil, 25mm disks, thickness 0.01mm, 99.9%

GF53882477

Nickel, foil, light tested, 50x50mm, thickness 0.01mm, 99.95%

GF70289859

Nickel, foil, light tested, 100x100mm, thickness 0.05mm, as rolled, 99.99+%

GF49959477

Nickel, foil, not light tested, 100x100mm, thickness 0.008mm, 99.95%

GF81498077

Nickel, foil, light tested, 150x150mm, thickness 0.0125mm, 99.9%