- Dynamic nuclear polarization of biocompatible (13)C-enriched carbonates for in vivo pH imaging.
Dynamic nuclear polarization of biocompatible (13)C-enriched carbonates for in vivo pH imaging.
Chemical communications (Cambridge, England) (2016-01-23)
D E Korenchan, R R Flavell, C Baligand, R Sriram, K Neumann, S Sukumar, H VanBrocklin, D B Vigneron, D M Wilson, J Kurhanewicz
PMID26792559
ABSTRACT
A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized (13)C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized (13)C pH imaging in a phantom and in vivo in a murine model of prostate cancer.
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