- Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions.
Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions.
Chemical communications (Cambridge, England) (2018-03-13)
Suguru Yoshida, Kimiyuki Kanno, Isao Kii, Yoshihiro Misawa, Masatoshi Hagiwara, Takamitsu Hosoya
PMID29527608
ABSTRACT
A facile strategy for the synthesis of trifunctional molecules involving three sequential selective triazole-forming reactions is proposed. This method exploits three kinds of mechanistically different azido-type-selective cycloadditions. Three different azidophiles could be efficiently connected to a triazido platform molecule with three types of azido groups in a consecutive manner, which rendered a practical trifunctional molecule readily available.