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Discovery of ectoparasiticidal hydrazonotrifluoromethanesulfonanilides.

Bioorganic & medicinal chemistry letters (2009-12-08)
Abdelselam Ali, Petr Fisara, Jamie A Freemont, Stella Kyi, Adam G Meyer, Andrew G Riches, Roger M Sargent, David G Sawutz, Kathleen A Turner, Kevin N Winzenberg, Qi Yang
ABSTRACT

A series of hydrazonotrifluorosulfonanilide derivatives were synthesized and evaluated for in vitro activity against the ectoparasites Ctenocephalides felis and Rhipicephalus sanguineus. Some compounds with excellent activity against tick were identified.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
1-Aminohydantoin hydrochloride, 98%