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47437

Sigma-Aldrich

Fmoc-D-Tic-OH

≥98.0% (TLC)

Synonym(s):

(R)-N-Fmoc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

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About This Item

Empirical Formula (Hill Notation):
C25H21NO4
CAS Number:
130309-33-0
Molecular Weight:
399.44
Beilstein:
7499344
MDL number:
MFCD00144345
UNSPSC Code:
12352200
PubChem Substance ID:
57650954

Assay

≥98.0% (TLC)

optical activity

[α]20/D −25.0±2°, c = 0.6% in methanol

application(s)

peptide synthesis

functional group

Fmoc

storage temp.

2-8°C

SMILES string

OC(=O)[C@H]1Cc2ccccc2CN1C(=O)OCC3c4ccccc4-c5ccccc35

InChI

1S/C25H21NO4/c27-24(28)23-13-16-7-1-2-8-17(16)14-26(23)25(29)30-15-22-20-11-5-3-9-18(20)19-10-4-6-12-21(19)22/h1-12,22-23H,13-15H2,(H,27,28)/t23-/m1/s1

InChI key

LIRBCUNCXDZOOU-HSZRJFAPSA-N

Other Notes

FMOC-D-Tic is employed e.g. for the solid-phase synthesis of Bradykinin antagonists

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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C Thurieau et al.
Journal of medicinal chemistry, 39(10), 2095-2101 (1996-05-10)
We report here on the synthesis and pharmacological properties of a new series of small linear and cyclic peptides derived from the five C-terminal amino acid residues of second-generation bradykinin receptor antagonists. Variations of the two first residues of the
V S Goodfellow et al.
Journal of medicinal chemistry, 39(7), 1472-1484 (1996-03-29)
We report a systematic probing of the structural requirements of the bradykinin (BK) type 2 (B(2)) receptor for antagonist activity by incorporating N-alkyl-amino acid residues at positions 7 and 8 of a potent antagonist sequence. Compound 1 (D-Arg(0)-Arg(1)-Pro(2)-Hyp(3)-Gly(4)-Thi(5)-Ser(6)-D-Tic(7)-N-Chg (8)-Arg(9), CP-0597)(1,2)

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